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In addition, the application of exendin-4, a GLP-1RA in obese mice triggered by diet restores C1q/TNF-related protein 3 (CTRP3) expression in keratinocytes, thereby inhibiting STAT3 phosphorylation via lysosomal-associated membrane protein 1 (LAMP1) and alleviating the psoriatic symptoms induced by imiquimod treatment [204]

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This is because allicin, the compound that gives garlic its characteristic odor and flavor, is released when garlic is crushed or chopped

This eliminates the need to stretch a vial past its safe use date

Despite these limitations, this study validates the safety of combined cagrilintide and semaglutide pharmacotherapy, justifying additional studies to evaluate efficacy for weight management in obesity